0038 Separating Circadian- and Behavior-Driven Metabolite Rhythms in Simulated Shift Work
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چکیده
منابع مشابه
Changing the Waveform of Circadian Rhythms: Considerations for Shift-Work
Circadian disruption in shift-work is common and has deleterious effects on health and performance. Current efforts to mitigate these harms reasonably focus on the phase of the circadian pacemaker, which unfortunately in humans, shifts slowly and often incompletely. Temporal reorganization of rhythmic waveform (i.e., the shape of its 24 h oscillation), rather than phase, however, may better mat...
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There has been scant evidence for a phase-shifting effect of melatonin in shift-work or jet-lag protocols. This study tested whether melatonin can facilitate phase shifts in a simulated night-work protocol. Subjects (n = 32) slept in the afternoons/evenings before night work (a 7-h advance of the sleep schedule). They took melatonin (0.5 mg or 3.0 mg) or placebo before the first four of eight a...
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Changes in individuals’ sleep-wake cycles lead to negative side effects. This review considers how side effects can be reduced, the recommendations being based largely on work performed at our institute. Subjects journeying to Australia had symptoms of jet lag that did not adjust synchronously, and the best predictors of jet lag were their travel arrangements. The value of melatonin in reducing...
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Health impairments, including reproductive issues, are associated with working nights or rotating shifts. For example, shift work has been associated with an increased risk of irregular menstrual cycles, endometriosis, infertility, miscarriage, low birth weight or pre-term delivery, and reduced incidence of breastfeeding. Based on what is known about circadian regulation of endocrine rhythms in...
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ژورنال
عنوان ژورنال: Sleep
سال: 2018
ISSN: 0161-8105,1550-9109
DOI: 10.1093/sleep/zsy061.037